• Preoperative Radiosurgery in Brain Tumors
    - The Radiosurgery Society

    There is growing interest among the medical community in using irradiation – or radiosurgery – as a pre-operative treatment for brain tumors. A webinar held by The Radiosurgery Society covers the latest research, clinical evidence, and rationale for using pre- operative radiosurgery to treat brain tumors. Dr. Victor Mangona of Texas Center for Proton Therapy noted that it is not uncommon for patients with brain tumors to have a dominant mass, as well as smaller lesions, and pre-operative radiosurgery has the potential to simultaneously treat presenting symptoms like these, while gathering a pathology report of the patient’s tumor. Additionally, patients may also benefit from faster time to treatment because they would not have to wait on post-operative recovery, before undergoing irradiation treatment.

  • A Better Way To Irradiate Lethal CNS Metastases? Randomized Trial Makes Case for Proton Craniospinal Irradiation for Leptomeningeal Spread
    - American Society of Clinical Oncology

    Interim analysis of a Phase II study of patients with metastatic lung and breast cancers indicates that proton craniospinal irradiation therapy can mitigate disease progression in the central nervous system and improve overall survival when used to treat patients whose disease has metastasized into the leptomeningeal space surrounding the brain and spinal cord. Survival for patients with this disease is four to six months with standard irradiation treatments, such as whole-brain radiotherapy (WBRT) or focal spine radiotherapy. While these therapies relieve symptoms, they do not stop progression in the leptomeningeal space or prolong survival. Whereas analysis of the study indicated proton craniospinal irradiation therapy increased survival from six months to 9.9 months. Additionally, results showed that 92 percent of patients receiving standard photon involved-field radiotherapy (IFRT) saw disease progression in the central nervous system at six months – compared to only 22 percent of patients who received proton craniospinal irradiation.