Proton Therapy News and Research
Proton therapy is an advanced, highly precise form of radiation that uses protons to destroy cancer cells while minimizing damage to the surrounding tissue. Every day, research teams and medical experts work with patients through in-depth studies and leading-edge trials. These studies address challenges and identify ways to better treat, diagnose, and prevent cancer.
This page features proton therapy industry news, academic and scientific journal articles, groundbreaking research, and commentary from the physicians and leaders at Texas Center Proton Therapy.
In a First, Proton Therapy Bests Radiotherapy in an RCT
- Medscape Medical News
This article explores the results of a randomized controlled trial in patients with esophageal cancer. Authors of the study, published in the Journal of Clinical Oncology on July 25, 2020, report that proton therapy significantly reduced toxicity in patients who participated in the trial. The article includes commentary of independent peers within the industry.
Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer
- Journal of Clinical Oncology
A randomized trial of patients with esophageal cancer compared total toxicity burden and progression-free survival between two modalities: intensity-modulated radiation therapy (IMRT) and proton beam therapy. Total toxicity burden rates were lower for patients treated with proton beam therapy versus IMRT, concluding that for locally advanced esophageal cancer, proton beam therapy reduced the risk and severity of adverse events compared with IMRT.
Efficacy and Safety of Locoregional Radiotherapy With Chemotherapy vs Chemotherapy Alone in De Novo Metastatic Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial
- JAMA Oncolog
Research continues to demonstrate the crucial role of radiation therapy in cancer care. New research demonstrates that even in patients with the most advanced nasopharyngeal carcinomas who have isolated metastasis, there is a benefit for adding local radiation therapy. In this recent study they use the most advanced radiation technique available to them, IMRT, however patients in Texas have an even more advanced radiation technique to reduce toxicity and extend life by using proton therapy, a specialized form of radiation therapy that excels at the treatment of nasopharyngeal carcinoma. Prior studies have demonstrated that proton therapy has superior dosimetry and should allow these most advanced patients to get their treatment with as little toxicity as possible so they can continue their lives with minimal residual side effects.
Incidence and Onset of Severe Cardiac Events After Radiotherapy for Esophageal Cancer
- Journal of Thoracic Oncology
The relatively higher cardiac dose exposure for esophageal cancer may result in the earlier onset of cardiac diseases, according to a study of 479 patients with esophageal cancer. The study examined incidence, onset, and long-term survival outcomes of high-grade cardiac events following radiotherapy, the results of which conclude severe cardiac events were relatively common in patients with early onset esophageal cancer after radiotherapy, especially those with preexisting cardiac disease and higher radiation doses to the heart.
Second Cancer Risk After Primary Cancer Treatment With Three-dimensional Conformal, Intensity-modulated, or Proton Beam Radiation Therapy
- ACS Journals
In a study of 450,373 pediatric and adult patients with a first cancer diagnoses between 2004 and 2015 who received 3-dimensional conformal radiotherapy, intensity-modulated radiotherapy (IMRT), or proton beam therapy, overall, the incidence of a second cancer diagnosis was less likely to occur in patients whose primary cancer was treated with proton beam therapy. There was no overall difference in the risk of second cancer in patients who received 3-dimensional conformal radiotherapy versus IMRT.
Superior Intellectual Outcomes After Proton Radiotherapy Compared with Photon Radiotherapy for Pediatric Medulloblastoma
- Journal of Clinical Oncology
Pediatric patients with medulloblastoma responded more favorably in this first known study to compare intellectual trajectories between those treated with proton radiotherapy versus those treated with photon radiotherapy. Proton radiotherapy may lessen the neuropsychological risk traditionally associated with cranial radiotherapy for the treatment of pediatric brain tumors by reducing the dose to normal tissue compared with that of photon radiotherapy.
Comparative Effectiveness of Proton vs. Photon Therapy as Part of Concurrent Chemoradiotherapy for Locally Advanced Cancer
- Journal of the American Medical Association
In this analysis, the authors evaluated 1,483 adults with nonmetastatic cancer for the risk of severe adverse events associated with unplanned hospitalizations with concurrent proton-based chemoradiotherapy for patients undergoing conventional photon radiotherapy. The findings suggest that proton-based chemoradiotherapy was associated with significantly reduced adverse events that caused unplanned hospitalizations, with similar disease-free and overall survival.