Proton Therapy for Pancreatic Cancer

Pancreatic Cancer Statistics

• Pancreatic cancer ranks as the third deadliest cancer in the United States after cancers of the lung and colon.
• In 2023, an estimated 64,050 people will be diagnosed, and 50,550 deaths are expected in the U.S.
• In 2023, Texas is estimated to have 4,570 new cases of pancreatic cancer and 3,510 expected deaths.

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Pancreatic Cancer Risk Factors

• Age: The risk of pancreatic cancer increases with age, with nearly all patients diagnosed after age 45, and about two out of three people are 65 years of age or older. The average age at diagnosis is 70.
• Race: Ashkenazi Jews and African Americans face a higher risk of pancreatic cancer than Caucasians.
• Tobacco: People who smoke cigarettes are approximately twice as likely to have pancreatic cancer. Using smokeless tobacco products or smoking cigars or pipes also increases risk. Smoking is thought to cause about 20 to 30 percent of pancreatic cancers.
• Weight: Those who are obese and those with extra weight around the waist face an increased risk of the disease.
• Family History: Those with a family history of the disease have an increased risk. In some cases, the incidence of pancreatic cancer in a family may be associated with a genetic mutation. Genetic tests may identify a person’s risk.
• Health Conditions: Pancreatic cancer is more common in diabetics. Chronic pancreatitis due to a gene mutation, cirrhosis of the liver, or the bacteria H. pylori also increase risk.
• Industrial Exposure: Working with chemicals used in dry cleaning and metal working increases risk.

Pancreatic Cancer Symptoms and Signs

Because the pancreas is located deep in the body, physicians often are unable to detect tumors during a regular checkup. When symptoms begin to appear, pancreatic cancer has often grown to an advanced stage and metastasized to surrounding organs, leading to a lower survival rate. If any of these symptoms are experienced, consult a physician:

• Yellowing of the skin or eyes
• Mid-back or abdomen pain
• Diabetes
• Unexplained weight loss
• Difficulty digesting foods
• Swelling of the gallbladder or liver
• Pale stools or dark urine
• Itching
• Nausea or vomiting
• Blood clots
• Weakness or fatigue
• Appetite loss
• Stomach bloating or discomfort
• Chills, sweats, and fever

Pancreatic Cancer Prevention

While there is no definitive way to prevent pancreatic cancer, men and women can actively take steps to decrease their risk. Because smokers face a significantly increased risk, everyone should avoid smoking, as the use of tobacco also increases risk for a number of cancer types. Heavy alcohol consumption can lead to certain conditions that increase pancreatic cancer risk, such as chronic pancreatitis and cirrhosis, and should also be avoided. In addition, obesity can further complicate pancreatic cancer, so maintaining a healthy body weight through proper nutrition and consistent physical activity is recommended.

Pancreatic Cancer Treatment

Treatment options for pancreatic cancer patients often include surgery, radiation therapy, proton therapy, chemotherapy, targeted therapy, immunotherapy, ablation or embolization treatment, or palliative therapy. A combination of treatments may provide the best chance of disease control. In addition, clinical trials are conducted to identify new cancer therapies to improve treatment outcomes. Through participation in clinical trials, patients can help physicians identify new and promising drugs while expanding treatment options.