Proton Therapy for Sarcoma

Sarcomas are cancers of connective tissue. They fall into groups based on whether they arise in soft tissue or bone.

  • Soft tissue sarcomas can originate from cells of muscle, fat, nerve, fibrous tissue, deep skin tissue or blood vessels. However, in many cases, the cell of origin is unknown. Soft tissue sarcomas most frequently are found in the arms or the legs, but can occur anywhere in the body.
  • Bone sarcomas more commonly occur in adolescents and young adults. The most common types are osteosarcoma and Ewing sarcoma. Osteosarcoma, a cancer of the part of the bone that gives bone its strength, is found most often in the bones around the knee. Ewing sarcoma most often occurs in the bones of the pelvis, chest wall, or the middle of long leg bones, but can also presents in the muscles.

These tumors are different from other “cancers of the bone” such as breast cancer, which spreads to bone, or multiple myeloma, which arises from blood cells in the bone marrow.

Learn more about sarcoma, a 'forgotten cancer.'

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Benefits of Proton Therapy for Sarcoma

  • High-energy, precisely-targeted proton beams can deliver high doses of radiation to destroy cancerous cells, reducing recurrence rates for many cancer cases.
  • Proton therapy is non-invasive and may reduce side effects.
  • Patients treated with proton therapy may have increased tolerance for chemotherapy.
  • Patients can maintain their current quality of life during and after treatment.
  • It is sometimes used effectively to treat areas that have already been treated with radiation.

Sarcoma Statistics

  • Sarcomas account for about 1% of adult cancers and about 15% of childhood cancers.
  • In the U.S., about 13,400 new cases of soft tissue sarcoma are expected to be diagnosed in 2023, with approximately 5,140 deaths.
  • Approximately 3,970 new cases of bone and joint cancer are expected to be diagnosed in the U.S. in 2023, with an estimated 2,140 deaths.
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Sarcoma Risk Factors

There are no known reasons for developing sarcomas, but certain risk factors have been identified based on common characteristics in individuals who developed the disease, including:

  • History of high doses of radiation exposure from treatments for other cancers; however, radiation treatment techniques have improved to ensure the targeted area is treated more precisely so effects on surrounding tissues and organs are minimized.
  • Individuals exposed to herbicides with high doses of phenoxyacetic acid and wood preservatives with chlorophenols have a higher risk.
  • Individuals with certain inherited diseases, including Li-Fraumeni syndrome, retinoblastoma, Paget’s disease of bone, multiple exostoses syndrome, Gardner syndrome, Werner syndrome, Gorlin syndrome, von Recklinghausen disease (neurofibromatosis), or tuberous sclerosis have an increased risk of developing a soft tissue or bone sarcoma.
  • Damage to a person’s lymph system, which can occur through surgery or radiation therapy, is also a risk factor associated with soft tissue sarcoma.

Sarcoma Symptoms and Signs

In the early stages, it can be difficult to determine if a sarcoma is present, and sarcoma may go undetected for a long period of time. Symptoms such as bone pain, suspicious lumps, or swollen areas of the body should be evaluated by a physician, who may conduct a biopsy If a lump is present to determine if it is a malignant tumor or benign. Over time, tumors can grow, become sore, and eventually cause pain, bone fracturing, swelling, numbness, tingling, or weakness as the tumor presses against nerves or muscles.

Sarcoma Prevention

There are no known ways to prevent the development of a bone or soft-tissue sarcoma. Maintaining a healthy lifestyle and getting regular check-ups are the best ways to reduce the risk for developing all forms of cancer.

Sarcoma Treatment

Once a sarcoma is diagnosed, the treatment plan will be based on type, location, and stage of the cancer, as well as the patient’s overall health and individual goals. Surgery may be an option, depending on the cancer’s location and stage. For soft tissue sarcoma, tissue is sometimes removed even if the disease has spread to other areas. Chemotherapy or radiation therapy may be used to shrink the tumor before surgery. Following surgery, patients may receive radiation therapy or chemotherapy to improve the chances of eliminating all tumor cells. Proton therapy, targeted therapy, immunotherapy, and palliative medicine may also be treatment options.  Patients with sarcoma are usually treated by a multidisciplinary team including surgical oncology or orthopedic oncology, medical oncology, radiation oncology and palliative care.  Enrollment into clinical trials may also be considered.

Source: American Cancer Society, American Society of Clinical Oncology, Sarcoma Foundation of America

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